deltatrials
Completed PHASE2 INTERVENTIONAL 5-arm NCT04676737

TTHX1114(NM141) in Combination With DWEK/DSO

Phase 2 Study To Determine the Safety and Efficacy of TTHX1114(NM141) on the Regeneration and Migration of Corneal Endothelial Cells in Patients Undergoing DWEK/DSO

Sponsor: Trefoil Therapeutics, Inc.

Interventions TTHX1114(NM141)
Updated 10 times since 2021 Last updated: Nov 6, 2023 Started: Feb 1, 2021 Primary completion: Nov 16, 2022 Completion: Jan 13, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Fuchs and Fuchs Dystrophy, this trial is completed. The trial is conducted by Trefoil Therapeutics, Inc. and has accumulated 10 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Feb 2022 · 4 months · monthly snapshot~Feb 2022 – ~Oct 2023 · 20 months · monthly snapshotActive Not Recruiting~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 10 months · monthly snapshotCompleted

Change History

10 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Unknown StatusCompleted

  5. Oct 2023 — Dec 2023 [monthly]

    Unknown Status PHASE2

    Status: Active Not RecruitingUnknown Status

Show 5 earlier versions
  1. Feb 2022 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  2. Oct 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  3. Jun 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  4. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  5. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Trefoil Therapeutics, Inc.
Data source: Trefoil Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .