deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT04688775

Eptinezumab in Participants With Episodic Cluster Headache (ALLEVIATE)

Interventional, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Delayed-Start Study to Evaluate the Efficacy and Safety of Eptinezumab in Patients With Episodic Cluster Headache

Sponsor: H. Lundbeck A/S

Conditions Cluster Headache, Episodic
Interventions Eptinezumab Placebo
Updated 27 times since 2021 Last updated: Jul 16, 2024 Started: Dec 23, 2020 Primary completion: Jun 14, 2023 Completion: Oct 5, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Cluster Headache, Episodic and is currently completed. H. Lundbeck A/S leads this study, which shows 27 recorded versions since 2020 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Nov 2023 · 3 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  5. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

▶ Show 22 earlier versions

  1. Aug 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  2. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  3. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE3

  4. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE3

  5. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE3

  6. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  7. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE3

  8. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE3

  9. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  10. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  11. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  12. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  13. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  14. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  15. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  16. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  17. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  18. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  19. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  20. Apr 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  21. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  22. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

    First recorded

Dec 2020

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • H. Lundbeck A/S
Data source: H. Lundbeck A/S

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aarhus N, Denmark , Almada, Portugal , Amadora, Portugal , Amherst, United States , Amsterdam, Netherlands , Ann Arbor, United States , Athens, Greece , Barcelona, Spain , Bari, Italy , Berlin, Germany and 94 more locations