deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 1-arm NCT04690595

BAFFR Targeting CAR-T Cells for the Treatment of Relapsed or Refractory B-cell ALL

A Phase 1 Study Evaluating BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia

Sponsor: City of Hope Medical Center

Interventions BAFFR-CAR T cells
Updated 19 times since 2021 Last updated: Feb 9, 2026 Started: May 18, 2021 Primary completion: Nov 18, 2026 Completion: Nov 18, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04690595, this PHASE1 trial focuses on Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia and remains ongoing. Sponsored by City of Hope Medical Center, it has been updated 19 times since 2021, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Nov 2022 · 5 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Mar 2023 · 3 months · monthly snapshot~Mar 2023 – ~May 2023 · 2 months · monthly snapshot~May 2023 – ~Mar 2024 · 10 months · monthly snapshot~Mar 2024 – ~Jun 2024 · 3 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Aug 2025 · 11 months · monthly snapshot~Aug 2025 – ~Feb 2026 · 6 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

19 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  2. Aug 2025 — Feb 2026 [monthly]

    Recruiting PHASE1

  3. Sep 2024 — Aug 2025 [monthly]

    Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  5. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

Show 14 earlier versions
  1. Mar 2024 — Jun 2024 [monthly]

    Recruiting PHASE1

  2. May 2023 — Mar 2024 [monthly]

    Recruiting PHASE1

  3. Mar 2023 — May 2023 [monthly]

    Recruiting PHASE1

  4. Dec 2022 — Mar 2023 [monthly]

    Recruiting PHASE1

  5. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  6. Jun 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  7. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  8. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  9. Feb 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

    Status: Active Not RecruitingRecruiting

  10. Dec 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1

  11. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1

  12. Sep 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  13. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  14. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • City of Hope Medical Center
  • PeproMene Bio, Inc.
Data source: PeproMene Bio, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations