The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias
Sponsor: Children's Oncology Group
Listed as NCT04726241, this PHASE1/PHASE2 trial focuses on Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia and remains actively recruiting participants. Sponsored by Children's Oncology Group, it has been updated 33 times since 2022, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Study Description(click to expand)PRIMARY OBJECTIVES:
I. To utilize clinical and biological characteristics of acute leukemias to screen for patient eligibility for available phase I/II Pediatric Acute Leukemia (PedAL) sub-trials.
II. To maintain a longitudinal and comprehensive registry, as well as a specimen bank, from relapse in children and young adults with acute leukemias.
OUTLINE:
Patients undergo collection of blood and/or bone marrow samples at baseline, end of treatment cycle(s), and at relapse/refractory disease status (if applicable).
After completion of study, patients are followed up every 3 months for 2 years, and then every 6 months for 3 years.
PRIMARY OBJECTIVES:
I. To utilize clinical and biological characteristics of acute leukemias to screen for patient eligibility for available phase I/II Pediatric Acute Leukemia (PedAL) sub-trials.
II. To maintain a longitudinal and comprehensive registry, as well as a specimen bank, from relapse in children and young adults with acute leukemias.
OUTLINE:
Patients undergo collection of blood and/or bone marrow samples at baseline, end of treatment cycle(s), and at relapse/refractory disease status (if applicable).
After completion of study, patients are followed up every 3 months for 2 years, and then every 6 months for 3 years.
Status Flow
Change History
33 versions recorded-
Mar 2026 — Present [monthly]
Recruiting PHASE1/PHASE2
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Feb 2026 — Present [monthly]
Recruiting PHASE1/PHASE2
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Feb 2026 — Present [monthly]
Recruiting PHASE1/PHASE2
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Jan 2026 — Present [monthly]
Recruiting PHASE1/PHASE2
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Nov 2025 — Feb 2026 [monthly]
Recruiting PHASE1/PHASE2
▶ Show 28 earlier versions
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Oct 2025 — Nov 2025 [monthly]
Recruiting PHASE1/PHASE2
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Sep 2025 — Oct 2025 [monthly]
Recruiting PHASE1/PHASE2
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Aug 2025 — Sep 2025 [monthly]
Recruiting PHASE1/PHASE2
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Jul 2025 — Aug 2025 [monthly]
Recruiting PHASE1/PHASE2
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Jun 2025 — Jul 2025 [monthly]
Recruiting PHASE1/PHASE2
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Apr 2025 — Jun 2025 [monthly]
Recruiting PHASE1/PHASE2
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Mar 2025 — Apr 2025 [monthly]
Recruiting PHASE1/PHASE2
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Jan 2025 — Mar 2025 [monthly]
Recruiting PHASE1/PHASE2
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Nov 2024 — Jan 2025 [monthly]
Recruiting PHASE1/PHASE2
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Oct 2024 — Nov 2024 [monthly]
Recruiting PHASE1/PHASE2
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Sep 2024 — Oct 2024 [monthly]
Recruiting PHASE1/PHASE2
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Jul 2024 — Sep 2024 [monthly]
Recruiting PHASE1/PHASE2
Phase: PHASE1_PHASE2 → PHASE1/PHASE2
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May 2024 — Jul 2024 [monthly]
Recruiting PHASE1_PHASE2
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Mar 2024 — May 2024 [monthly]
Recruiting PHASE1_PHASE2
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Feb 2024 — Mar 2024 [monthly]
Recruiting PHASE1_PHASE2
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Jan 2024 — Feb 2024 [monthly]
Recruiting PHASE1_PHASE2
Phase: PHASE2 → PHASE1_PHASE2
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Dec 2023 — Jan 2024 [monthly]
Recruiting PHASE2
Phase: NA → PHASE2
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Jun 2023 — Dec 2023 [monthly]
Recruiting NA
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May 2023 — Jun 2023 [monthly]
Recruiting NA
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Apr 2023 — May 2023 [monthly]
Recruiting NA
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Feb 2023 — Apr 2023 [monthly]
Recruiting NA
Phase: None → NA
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Jan 2023 — Feb 2023 [monthly]
Recruiting
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Nov 2022 — Jan 2023 [monthly]
Recruiting
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Sep 2022 — Nov 2022 [monthly]
Recruiting
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Jul 2022 — Sep 2022 [monthly]
Recruiting
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Jun 2022 — Jul 2022 [monthly]
Recruiting
Status: Not Yet Recruiting → Recruiting
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Dec 2021 — Jun 2022 [monthly]
Not Yet Recruiting
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Feb 2021 — Dec 2021 [monthly]
Not Yet Recruiting
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Children's Oncology Group
- National Cancer Institute (NCI)
- PedAL BCU, LLC
For direct contact, visit the study record on ClinicalTrials.gov .