deltatrials
Recruiting PHASE2 INTERVENTIONAL 1-arm NCT04728893

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

A Phase 2 Study to Evaluate the Efficacy and Safety of MK-1026 in Participants With Hematologic Malignancies

Sponsor: Merck Sharp & Dohme LLC

Interventions Nemtabrutinib
Updated 54 times since 2021 Last updated: Feb 10, 2026 Started: Apr 5, 2021 Primary completion: Jan 4, 2029 Completion: Jan 4, 2029
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04728893, this PHASE2 trial focuses on Chronic Lymphocytic Leukaemia and Hematologic Malignancies and remains actively recruiting participants. Sponsored by Merck Sharp & Dohme LLC, it has been updated 54 times since 2021, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Feb 2021 – ~May 2021 · 3 months · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Oct 2022 · 30 days · monthly snapshot~Oct 2022 – ~Nov 2022 · 31 days · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

54 versions recorded
  1. Feb 2026 — Present [monthly]

    Recruiting PHASE2

  2. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE2

  3. Dec 2025 — Jan 2026 [monthly]

    Recruiting PHASE2

  4. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE2

  5. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE2

Show 49 earlier versions
  1. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE2

  2. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE2

  3. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE2

  4. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE2

  5. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE2

  6. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE2

  7. Jan 2025 — Apr 2025 [monthly]

    Recruiting PHASE2

  8. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE2

  9. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE2

  10. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE2

  11. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE2

  12. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  13. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  14. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  15. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE2

  16. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE2

  17. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE2

  18. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE2

  19. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE2

  20. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  21. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE2

  22. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  23. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  24. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  25. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  26. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  27. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  28. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  29. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  30. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  31. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE2

  32. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  33. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  34. Oct 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  35. Sep 2022 — Oct 2022 [monthly]

    Recruiting PHASE2

  36. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  37. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  38. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  39. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  40. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  41. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  42. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  43. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  44. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  45. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  46. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  47. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  48. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  49. Feb 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Merck Sharp & Dohme LLC
Data source: Merck Sharp & Dohme LLC

For direct contact, visit the study record on ClinicalTrials.gov .