Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT04762758

Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients (PREMIER)

A Multi-center, Randomized, Double-blind, Placebo Controlled Phase III Study to Assess the Efficacy, Safety, and Tolerability of PXT3003 in Charcot-Marie-Tooth Type 1A (CMT1A)

Sponsor: Pharnext S.C.A.

Conditions Charcot-Marie-Tooth Disease

Interventions (RS)-baclofen, naltrexone hydrochloride and D-sorbitol Placebo

Updated 22 times since 2021 Last updated: Apr 2, 2024 Started: Mar 30, 2021 Primary completion: Apr 19, 2024 Completion: Apr 19, 2024

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Charcot-Marie-Tooth Disease and is currently ongoing. Pharnext S.C.A. leads this study, which shows 22 recorded versions since 2021 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

22 versions recorded

Sep 2025 — Present [monthly]

Active Not Recruiting PHASE3
Sep 2024 — Sep 2025 [monthly]

Active Not Recruiting PHASE3
Jul 2024 — Sep 2024 [monthly]

Active Not Recruiting PHASE3
May 2024 — Jul 2024 [monthly]

Active Not Recruiting PHASE3
Dec 2023 — May 2024 [monthly]

Active Not Recruiting PHASE3

▶ Show 17 earlier versions

May 2023 — Dec 2023 [monthly]

Active Not Recruiting PHASE3
Apr 2023 — May 2023 [monthly]

Active Not Recruiting PHASE3
Nov 2022 — Apr 2023 [monthly]

Active Not Recruiting PHASE3
Sep 2022 — Nov 2022 [monthly]

Active Not Recruiting PHASE3
Jun 2022 — Sep 2022 [monthly]

Active Not Recruiting PHASE3
May 2022 — Jun 2022 [monthly]

Active Not Recruiting PHASE3

Status: Recruiting → Active Not Recruiting
Apr 2022 — May 2022 [monthly]

Recruiting PHASE3
Mar 2022 — Apr 2022 [monthly]

Recruiting PHASE3
Jan 2022 — Mar 2022 [monthly]

Recruiting PHASE3
Dec 2021 — Jan 2022 [monthly]

Recruiting PHASE3
Nov 2021 — Dec 2021 [monthly]

Recruiting PHASE3
Oct 2021 — Nov 2021 [monthly]

Recruiting PHASE3
Sep 2021 — Oct 2021 [monthly]

Recruiting PHASE3
Jun 2021 — Sep 2021 [monthly]

Recruiting PHASE3
May 2021 — Jun 2021 [monthly]

Recruiting PHASE3
Apr 2021 — May 2021 [monthly]

Recruiting PHASE3

Status: Not Yet Recruiting → Recruiting
Mar 2021 — Apr 2021 [monthly]

Not Yet Recruiting PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Pharnext S.C.A.
Worldwide Clinical Trials

Data source: Pharnext S.C.A.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aachen, Germany , Angers, France , Austin, United States , Bordeaux, France , Boston, United States , Chapel Hill, United States , Charlotte, United States , Chicoutimi, Canada , Columbia, United States , Columbus, United States and 39 more locations