deltatrials
Completed PHASE1 INTERVENTIONAL 15-arm NCT04776317

Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults

A Phase 1 Trial to Evaluate the Safety, Immunogenicity, and Reactogenicity of Heterologous and Homologous Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults

Sponsor: Gritstone bio, Inc.

Conditions COVID-19
Interventions ChAdV68-S ChAdV68-S-TCE SAM-LNP-S SAM-LNP-S-TCE Sodium Chloride, 0.9%
Updated 29 times since 2021 Last updated: May 8, 2025 Started: Mar 25, 2021 Primary completion: Sep 15, 2023 Completion: Sep 15, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04776317, this PHASE1 trial focuses on COVID-19 and remains completed. Sponsored by Gritstone bio, Inc., it has been updated 29 times since 2021, reflecting substantial change activity. This study is part of the global effort to build evidence for infectious disease interventions.

Status Flow

~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Jun 2023 · 5 months · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Jun 2024 · 7 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Apr 2025 · 59 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

29 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Jun 2025 — Sep 2025 [monthly]

    Completed PHASE1

  3. May 2025 — Jun 2025 [monthly]

    Completed PHASE1

  4. Apr 2025 — May 2025 [monthly]

    Completed PHASE1

  5. Feb 2025 — Apr 2025 [monthly]

    Completed PHASE1

▶ Show 24 earlier versions

  1. Sep 2024 — Feb 2025 [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jun 2024 — Jul 2024 [monthly]

    Completed PHASE1

  4. Nov 2023 — Jun 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  5. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  6. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1

  7. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  8. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  9. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  10. Jan 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  11. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  12. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  13. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  14. Jun 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  15. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  16. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  17. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  18. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  19. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  20. Sep 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  21. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  22. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  23. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  24. Mar 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Gritstone bio, Inc.
  • National Institute of Allergy and Infectious Diseases (NIAID)
Data source: National Institute of Allergy and Infectious Diseases (NIAID)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations