A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus With Impaired Hypoglycemic Awareness and Severe Hypoglycemia
Sponsor: Vertex Pharmaceuticals Incorporated
Listed as NCT04786262, this PHASE3 trial focuses on Diabetes Mellitus, Type 1 and Impaired Hypoglycemic Awareness and remains actively recruiting participants. Sponsored by Vertex Pharmaceuticals Incorporated, it has been updated 23 times since 2021, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
23 versions recorded-
Sep 2025 — Present [monthly]
Recruiting PHASE3
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Aug 2025 — Sep 2025 [monthly]
Recruiting PHASE3
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Jun 2025 — Aug 2025 [monthly]
Recruiting PHASE3
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Apr 2025 — Jun 2025 [monthly]
Recruiting PHASE3
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Feb 2025 — Apr 2025 [monthly]
Recruiting PHASE3
▶ Show 18 earlier versions
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Jan 2025 — Feb 2025 [monthly]
Recruiting PHASE3
Phase: PHASE1/PHASE2 → PHASE3
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Nov 2024 — Jan 2025 [monthly]
Recruiting PHASE1/PHASE2
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Sep 2024 — Nov 2024 [monthly]
Recruiting PHASE1/PHASE2
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Jul 2024 — Sep 2024 [monthly]
Recruiting PHASE1/PHASE2
Phase: PHASE1_PHASE2 → PHASE1/PHASE2
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Nov 2023 — Jul 2024 [monthly]
Recruiting PHASE1_PHASE2
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Oct 2023 — Nov 2023 [monthly]
Recruiting PHASE1_PHASE2
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Sep 2023 — Oct 2023 [monthly]
Recruiting PHASE1_PHASE2
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Aug 2023 — Sep 2023 [monthly]
Recruiting PHASE1_PHASE2
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Jul 2023 — Aug 2023 [monthly]
Recruiting PHASE1_PHASE2
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Jun 2023 — Jul 2023 [monthly]
Recruiting PHASE1_PHASE2
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Mar 2023 — Jun 2023 [monthly]
Recruiting PHASE1_PHASE2
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Sep 2022 — Mar 2023 [monthly]
Recruiting PHASE1_PHASE2
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Jun 2022 — Sep 2022 [monthly]
Recruiting PHASE1_PHASE2
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Apr 2022 — Jun 2022 [monthly]
Recruiting PHASE1_PHASE2
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Mar 2022 — Apr 2022 [monthly]
Recruiting PHASE1_PHASE2
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Sep 2021 — Mar 2022 [monthly]
Recruiting PHASE1_PHASE2
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May 2021 — Sep 2021 [monthly]
Recruiting PHASE1_PHASE2
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Apr 2021 — May 2021 [monthly]
Recruiting PHASE1_PHASE2
First recorded
Mar 2021
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Vertex Pharmaceuticals Incorporated
For direct contact, visit the study record on ClinicalTrials.gov .