Completed PHASE3 INTERVENTIONAL 2-arm NCT04819269

Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome

Sponsor: Sylentis, S.A.

Conditions Dry Eye Disease Sjögren Syndrome

Interventions Tivanisiran sodium ophthalmic solution Vehicle ophthalmic solution

Updated 12 times since 2021 Last updated: Feb 16, 2024 Started: May 25, 2021 Primary completion: Dec 11, 2023 Completion: Dec 11, 2023

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Dry Eye Disease and Sjögren Syndrome and is currently completed. Sylentis, S.A. leads this study, which shows 12 recorded versions since 2021 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

12 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Mar 2024 — Jul 2024 [monthly]

Completed PHASE3

Status: Recruiting → Completed
Mar 2023 — Mar 2024 [monthly]

Recruiting PHASE3

▶ Show 7 earlier versions

Sep 2022 — Mar 2023 [monthly]

Recruiting PHASE3
Jul 2022 — Sep 2022 [monthly]

Recruiting PHASE3
Apr 2022 — Jul 2022 [monthly]

Recruiting PHASE3
Oct 2021 — Apr 2022 [monthly]

Recruiting PHASE3
Jun 2021 — Oct 2021 [monthly]

Recruiting PHASE3

Status: Not Yet Recruiting → Recruiting
May 2021 — Jun 2021 [monthly]

Not Yet Recruiting PHASE3
Apr 2021 — May 2021 [monthly]

Not Yet Recruiting PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Sylentis, S.A.

Data source: Sylentis, S.A.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Asheville, United States , Atlanta, United States , Aurora, United States , Barcelona, Spain , Birmingham, United States , Carmel, United States , Cleveland, United States , Colorado Springs, United States , Columbus, United States , Cranberry Township, United States and 34 more locations