deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT04836429

Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease

Utilizing Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-Small Cell Lung Cancer (NSCLC) With Pleural Disease or Malignant Pleural Mesothelioma (MPM) - Phase I Study

Sponsor: Roswell Park Cancer Institute

Conditions Lung Non-Small Cell Carcinoma Pleural Disorder
Interventions Intraoperative PDT Photodynamic Therapy Porfimer Sodium Video-Assisted Thoracic Surgery
Updated 14 times since 2021 Last updated: Feb 2, 2026 Started: Mar 10, 2022 Primary completion: Feb 3, 2024 Completion: Jan 3, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

low accrual

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This PHASE1 trial investigates Lung Non-Small Cell Carcinoma and Pleural Disorder and is currently terminated or withdrawn. Roswell Park Cancer Institute leads this study, which shows 14 recorded versions since 2022 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Jun 2022 · 6 months · monthly snapshot~Jun 2022 – ~Dec 2022 · 6 months · monthly snapshot~Dec 2022 – ~Apr 2023 · 4 months · monthly snapshot~Apr 2023 – ~Jul 2023 · 3 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Oct 2025 · 12 months · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Feb 2026 · 3 months · monthly snapshot~Feb 2026 – present · 6 months · monthly snapshot

Change History

14 versions recorded

  1. Feb 2026 — Present [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

  2. Nov 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Oct 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Oct 2024 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: Suspended → Active Not Recruiting

  5. Sep 2024 — Oct 2024 [monthly]

    Suspended PHASE1

▶ Show 9 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  2. Jul 2023 — Jul 2024 [monthly]

    Recruiting PHASE1

  3. Apr 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

  4. Dec 2022 — Apr 2023 [monthly]

    Recruiting PHASE1

  5. Jun 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  6. Dec 2021 — Jun 2022 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  7. Oct 2021 — Dec 2021 [monthly]

    Not Yet Recruiting PHASE1

  8. Sep 2021 — Oct 2021 [monthly]

    Not Yet Recruiting PHASE1

  9. May 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Roswell Park Cancer Institute
Data source: Roswell Park Cancer Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations