A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
A Phase I/Ib Global, Multicenter, Open-label Umbrella Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Sponsor: Hoffmann-La Roche
A observational or N/A phase clinical study on Metastatic Colorectal Cancer, this trial is actively recruiting participants. The trial is conducted by Hoffmann-La Roche and has accumulated 48 data snapshots since 2021. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.
Status Flow
Change History
48 versions recorded-
Apr 28, 2026 — Present [daily]
Recruiting
Phase: PHASE1 → None
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Mar 2026 — Apr 2026 [monthly]
Recruiting PHASE1
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Feb 2026 — Mar 2026 [monthly]
Recruiting PHASE1
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Jan 2026 — Feb 2026 [monthly]
Recruiting PHASE1
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Dec 2025 — Jan 2026 [monthly]
Recruiting PHASE1
▶ Show 43 earlier versions
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Nov 2025 — Dec 2025 [monthly]
Recruiting PHASE1
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Oct 2025 — Nov 2025 [monthly]
Recruiting PHASE1
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Sep 2025 — Oct 2025 [monthly]
Recruiting PHASE1
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Aug 2025 — Sep 2025 [monthly]
Recruiting PHASE1
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Jul 2025 — Aug 2025 [monthly]
Recruiting PHASE1
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Jun 2025 — Jul 2025 [monthly]
Recruiting PHASE1
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May 2025 — Jun 2025 [monthly]
Recruiting PHASE1
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Apr 2025 — May 2025 [monthly]
Recruiting PHASE1
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Mar 2025 — Apr 2025 [monthly]
Recruiting PHASE1
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Feb 2025 — Mar 2025 [monthly]
Recruiting PHASE1
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Jan 2025 — Feb 2025 [monthly]
Recruiting PHASE1
Status: Active Not Recruiting → Recruiting
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Nov 2024 — Jan 2025 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Oct 2024 — Nov 2024 [monthly]
Recruiting PHASE1
Status: Active Not Recruiting → Recruiting
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Sep 2024 — Oct 2024 [monthly]
Active Not Recruiting PHASE1
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Jul 2024 — Sep 2024 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Jun 2024 — Jul 2024 [monthly]
Recruiting PHASE1
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May 2024 — Jun 2024 [monthly]
Recruiting PHASE1
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Apr 2024 — May 2024 [monthly]
Recruiting PHASE1
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Mar 2024 — Apr 2024 [monthly]
Recruiting PHASE1
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Feb 2024 — Mar 2024 [monthly]
Recruiting PHASE1
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Jan 2024 — Feb 2024 [monthly]
Recruiting PHASE1
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Dec 2023 — Jan 2024 [monthly]
Recruiting PHASE1
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Nov 2023 — Dec 2023 [monthly]
Recruiting PHASE1
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Jul 2023 — Nov 2023 [monthly]
Recruiting PHASE1
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Jun 2023 — Jul 2023 [monthly]
Recruiting PHASE1
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May 2023 — Jun 2023 [monthly]
Recruiting PHASE1
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Apr 2023 — May 2023 [monthly]
Recruiting PHASE1
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Mar 2023 — Apr 2023 [monthly]
Recruiting PHASE1
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Feb 2023 — Mar 2023 [monthly]
Recruiting PHASE1
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Jan 2023 — Feb 2023 [monthly]
Recruiting PHASE1
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Nov 2022 — Jan 2023 [monthly]
Recruiting PHASE1
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Sep 2022 — Nov 2022 [monthly]
Recruiting PHASE1
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Jul 2022 — Sep 2022 [monthly]
Recruiting PHASE1
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Jun 2022 — Jul 2022 [monthly]
Recruiting PHASE1
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May 2022 — Jun 2022 [monthly]
Recruiting PHASE1
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Apr 2022 — May 2022 [monthly]
Recruiting PHASE1
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Mar 2022 — Apr 2022 [monthly]
Recruiting PHASE1
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Feb 2022 — Mar 2022 [monthly]
Recruiting PHASE1
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Jan 2022 — Feb 2022 [monthly]
Recruiting PHASE1
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Dec 2021 — Jan 2022 [monthly]
Recruiting PHASE1
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Nov 2021 — Dec 2021 [monthly]
Recruiting PHASE1
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Oct 2021 — Nov 2021 [monthly]
Recruiting PHASE1
Status: Not Yet Recruiting → Recruiting
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Sep 2021 — Oct 2021 [monthly]
Not Yet Recruiting PHASE1
First recorded
Eligibility Summary
This open-label, exploratory study is designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or combinations, in participants with metastatic colorectal cancer (mCRC) whose tumors are biomarker positive as per treatment arm-specific definition. Eligible participants with mCRC will be enrolled into specific treatment arms based on their biomarker assay results.
Contact Information
- Hoffmann-La Roche
For direct contact, visit the study record on ClinicalTrials.gov .