deltatrials
Completed PHASE4 INTERVENTIONAL 2-arm NCT04951206

Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus (VULVIE)

A Randomized Controlled Trial of Vulvar Fractionated CO2-Laser Therapy With and Without Concomitant Topical Clobetasol Propionate 0.05% Ointment for Treatment of Vulvar Lichen Sclerosus

Sponsor: Medstar Health Research Institute

Conditions Vulvar Lichen Sclerosus
Interventions Clobetasol Propionate 0.05% Ointment Fractionated CO2-laser
Updated 17 times since 2021 Last updated: Jun 2, 2025 Started: Mar 1, 2022 Primary completion: Apr 25, 2025 Completion: Apr 25, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Vulvar Lichen Sclerosus and is currently completed. Medstar Health Research Institute leads this study, which shows 17 recorded versions since 2022 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Jan 2023 · 6 months · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Jun 2023 · 3 months · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Jul 2024 · 10 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jul 2025 · 7 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

17 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE4

  2. Jul 2025 — Sep 2025 [monthly]

    Completed PHASE4

    Status: Active Not Recruiting → Completed

  3. Dec 2024 — Jul 2025 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  4. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE4

  5. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE4

▶ Show 12 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE4

  2. Sep 2023 — Jul 2024 [monthly]

    Recruiting PHASE4

  3. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE4

  4. Jun 2023 — Aug 2023 [monthly]

    Recruiting PHASE4

  5. Mar 2023 — Jun 2023 [monthly]

    Recruiting PHASE4

  6. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE4

  7. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE4

    Status: Active Not Recruiting → Recruiting

  8. Jul 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  9. May 2022 — Jul 2022 [monthly]

    Recruiting PHASE4

  10. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE4

    Status: Not Yet Recruiting → Recruiting

  11. Oct 2021 — Apr 2022 [monthly]

    Not Yet Recruiting PHASE4

  12. Sep 2021 — Oct 2021 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Medstar Health Research Institute
  • Patty Brisben Foundation For Women's Sexual Health
  • Society of Gynecologic Surgeons
Data source: Medstar Health Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations