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Terminated PHASE2 INTERVENTIONAL 2-arm NCT04971005

Ocrelizumab or Alemtuzumab Compared With Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis - a Phase-2 Randomised Controlled Trial (COAST)

A Randomised Controlled Trial to Compare Ocrelizumab or Alemtuzumab With Autologous Hematopoietic Stem Cell Transplantation (aHSCT) in High Inflammatory Multiple Sclerosis (COAST)

Sponsor: Clinical Trial Center North (CTC North GmbH & Co. KG)

Updated 5 times since 2021 Last updated: Mar 1, 2022 Started: Aug 27, 2021 Primary completion: Feb 4, 2022 Completion: Feb 4, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Lack of recruitment due to low acceptance of the control arm.

Other terminated trials from Clinical Trial Center North (CTC North GmbH & Co. KG)

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Listed as NCT04971005, this PHASE2 trial focuses on Relapsing-Remitting Multiple Sclerosis and remains terminated or withdrawn. Sponsored by Clinical Trial Center North (CTC North GmbH & Co. KG), it has been updated 5 times since 2021, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Apr 2022 · 5 months · monthly snapshotRecruiting~Apr 2022 – ~Jul 2024 · 27 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 23 months · monthly snapshotTerminated

Change History

5 versions recorded
  1. Sep 2024 — Present [monthly]

    Terminated PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  3. Apr 2022 — Jul 2024 [monthly]

    Terminated PHASE2

    Status: RecruitingTerminated

  4. Nov 2021 — Apr 2022 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  5. Sep 2021 — Nov 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Aug 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Clinical Trial Center North (CTC North GmbH & Co. KG)
  • Neovii Biotech
  • Universitätsklinikum Hamburg-Eppendorf
Data source: Universitätsklinikum Hamburg-Eppendorf

For direct contact, visit the study record on ClinicalTrials.gov .