Recruiting PHASE4 INTERVENTIONAL 3-arm NCT04974151

China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype (CSPPT2-TT)

Comparative Efficacy of Amlodipine Folic Acid vs. Amlodipine on the Risk of First Ischemic Stroke Among Participants With Hypertension and MTHFR 677 TT Genotype: A Multi-center, Randomized, Double-blind, Triple-dummy, Controlled Clinical Trial

Sponsor: Bozhou people's hospital

Conditions Hypertension MTHFR 677 TT Genotype

Interventions 5-MTHF Placebos 5-methyltetrahydrofolate (5-MTHF) Amlodipine besylate Amlodipine besylate And Folic Acid Amlodipine folic acid placebo Amlodipine placebo

Updated 7 times since 2021 Last updated: Feb 24, 2025 Started: Aug 22, 2024 Primary completion: Jun 30, 2029 Completion: Jun 30, 2029

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE4 clinical study on Hypertension and MTHFR 677 TT Genotype, this trial is actively recruiting participants. The trial is conducted by Bozhou people's hospital and has accumulated 7 data snapshots since 2024. Cardiovascular trials of this type often inform treatment guidelines for long-term patient management.

Status Flow

Change History

7 versions recorded

Jun 2025 — Present [monthly]

Recruiting PHASE4
Mar 2025 — Jun 2025 [monthly]

Recruiting PHASE4
Nov 2024 — Mar 2025 [monthly]

Recruiting PHASE4

Status: Not Yet Recruiting → Recruiting
Sep 2024 — Nov 2024 [monthly]

Not Yet Recruiting PHASE4
Jul 2024 — Sep 2024 [monthly]

Not Yet Recruiting PHASE4

▶ Show 2 earlier versions

May 2022 — Jul 2024 [monthly]

Not Yet Recruiting PHASE4
Sep 2021 — May 2022 [monthly]

Not Yet Recruiting PHASE4

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Bozhou people's hospital
Chengdu Fifth People's Hospital
Chizhou people's hospital
Deyang People's Hospital
First Affiliated Hospital of Gannan Medical University
Lianyungang Oriental Hospital
Lianyungang Second People's Hospital
Loudi Central Hospital
Peking University First Hospital
Second Affiliated Hospital of Nanchang University
Shenzhen Ausa Pharmed Co.,Ltd
Shenzhen Prospective Medical Technology Co., LTD
TAIHE country people's hospital
Tengzhou Central People's Hospital
The Affiliated Hospital Of Guizhou Medical University
The Affiliated Hospital Of Southwest Medical University
The First Affiliated Hospital of Bengbu Medical University
The First Affiliated Hospital of HuNan University of Medicine
The First People's Hospital of Lianyungang
Weinan Central Hospital
Yancheng First People's Hospital
Yangjiang People's Hospital

Data source: Shenzhen Ausa Pharmed Co.,Ltd

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Beijing, China , Bengbu, China , Bozhou, China , Chengdu, China , Chizhou, China , Deyang, China , Fuyang, China , Ganzhou, China , Guiyang, China , Huaihua, China and 8 more locations