deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT05001984

Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis (TOPICAL-MRI)

Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-label, Blinded End-point Study with High-resolution MR Vessel Wall Imaging

Sponsor: Chang Gung Memorial Hospital

Interventions Alirocumab
Updated 6 times since 2021 Last updated: Mar 23, 2025 Started: Aug 1, 2021 Primary completion: Apr 15, 2025 Completion: Apr 15, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Acute Ischemic Stroke and ICAS - Intracranial Atherosclerosis and is currently ongoing. Chang Gung Memorial Hospital leads this study, which shows 6 recorded versions since 2021 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2021 – ~Dec 2022 · 15 months · monthly snapshotRecruiting~Dec 2022 – ~Oct 2023 · 10 months · monthly snapshotRecruiting~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshotRecruiting~Apr 2025 – present · 15 months · monthly snapshotActive Not Recruiting

Change History

6 versions recorded
  1. Apr 2025 — Present [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  2. Sep 2024 — Apr 2025 [monthly]

    Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  4. Oct 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

  5. Dec 2022 — Oct 2023 [monthly]

    Recruiting PHASE2

Show 1 earlier version
  1. Sep 2021 — Dec 2022 [monthly]

    Recruiting PHASE2

    First recorded

Aug 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Chang Gung Memorial Hospital
  • Chang Gung University
Data source: Chang Gung Memorial Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations