deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT05008783

A Study of AK104 in the First-line Treatment of Locally Advanced Unresectable or Metastatic G/GEJ Adenocarcinoma

A Randomized, Double-blind, Multicenter, Phase III Study Comparing the Efficacy and Safety of AK104 Plus Oxaliplatin and Capecitabine (XELOX) Versus Placebo Plus XELOX as First-line Treatment for Locally Advanced Unresectable or G/GEJ Adenocarcinoma

Sponsor: Akeso

Interventions AK104 Placebo
Updated 8 times since 2021 Last updated: Nov 17, 2025 Started: Sep 17, 2021 Primary completion: Dec 6, 2024 Completion: Aug 1, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma, this trial is completed. The trial is conducted by Akeso and has accumulated 8 data snapshots since 2021. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshotRecruiting~Feb 2022 – ~Nov 2023 · 21 months · monthly snapshotRecruiting~Nov 2023 – ~May 2024 · 6 months · monthly snapshotRecruiting~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshotActive Not Recruiting~Apr 2025 – ~Dec 2025 · 8 months · monthly snapshotActive Not Recruiting~Dec 2025 – present · 8 months · monthly snapshotCompleted

Change History

8 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  2. Apr 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

Show 3 earlier versions
  1. Nov 2023 — May 2024 [monthly]

    Recruiting PHASE3

  2. Feb 2022 — Nov 2023 [monthly]

    Recruiting PHASE3

  3. Sep 2021 — Feb 2022 [monthly]

    Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Akeso
Data source: Akeso

For direct contact, visit the study record on ClinicalTrials.gov .