deltatrials
Completed PHASE2 INTERVENTIONAL 10-arm NCT05016882

Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH)

Efficacy and Safety Investigation of NNC0194-0499 Co-administered With Semaglutide in Subjects With Non-alcoholic Steatohepatitis: a Dose-ranging, Placebo Controlled Trial

Sponsor: Novo Nordisk A/S

Updated 43 times since 2021 Last updated: Nov 17, 2025 Started: Aug 31, 2021 Primary completion: Dec 17, 2024 Completion: Mar 14, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Non-alcoholic Steatohepatitis and is currently completed. Novo Nordisk A/S leads this study, which shows 43 recorded versions since 2021 — indicating substantial longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Dec 2022 · 7 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

43 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE2

  2. Oct 2025 — Dec 2025 [monthly]

    Completed PHASE2

  3. Sep 2025 — Oct 2025 [monthly]

    Completed PHASE2

  4. Jul 2025 — Sep 2025 [monthly]

    Completed PHASE2

  5. Jun 2025 — Jul 2025 [monthly]

    Completed PHASE2

Show 38 earlier versions
  1. May 2025 — Jun 2025 [monthly]

    Completed PHASE2

  2. Apr 2025 — May 2025 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  3. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jan 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

  6. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  8. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  9. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  10. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  11. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  12. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  13. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  14. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  15. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  16. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  17. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  18. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE2

  19. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  20. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  21. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  22. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  23. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  24. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  25. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  26. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  27. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  28. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE2

  29. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  30. May 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  31. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  32. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  33. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  34. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  35. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  36. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  37. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  38. Sep 2021 — Oct 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Aug 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novo Nordisk A/S
Data source: Novo Nordisk A/S

For direct contact, visit the study record on ClinicalTrials.gov .