Recruiting PHASE2 INTERVENTIONAL 2-arm NCT05051397

CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke (COMET-AIS)

Evaluation of the Effect of Moderate and Controlled Hypercapnia on Ischemic Penumbra Vascular Collaterality During General Anesthesia for Anterior Circulation Acute Ischemic Stroke Mechanical Thrombectomy

Sponsor: University Hospital, Clermont-Ferrand

Conditions Anesthesia, General Carbon Dioxide Cerebrovascular Circulation Ischemic Stroke, Acute Thrombectomy

Interventions HYPERCAPNIA NORMOCAPNIA

Updated 6 times since 2021 Last updated: Sep 30, 2025 Started: Jul 20, 2022 Primary completion: Jul 19, 2026 Completion: Oct 19, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Anesthesia, General and Carbon Dioxide and is currently actively recruiting participants. University Hospital, Clermont-Ferrand leads this study, which shows 6 recorded versions since 2022 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

6 versions recorded

Nov 2025 — Present [monthly]

Recruiting PHASE2

Status: Unknown → Recruiting
Jan 2025 — Nov 2025 [monthly]

Unknown PHASE2

Status: Recruiting → Unknown
Sep 2024 — Jan 2025 [monthly]

Recruiting PHASE2
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE2
Jan 2023 — Jul 2024 [monthly]

Recruiting PHASE2

Status: Not Yet Recruiting → Recruiting

▶ Show 1 earlier version

Oct 2021 — Jan 2023 [monthly]

Not Yet Recruiting PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

University Hospital, Clermont-Ferrand

Data source: University Hospital, Clermont-Ferrand

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Clermont-Ferrand, France