deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 5-arm NCT05077800

FOLFIRINOX + Elraglusib + Losartan In Pancreatic Cancer

A Phase II Study of FOLFIRINOX Combined With the Glycogen Synthase Kinase-3 Beta (GSK-3 β) Inhibitor Elraglusib and the Transforming Growth Factor-β (TGF-β) Inhibitor Losartan in Patients With Untreated Metastatic Pancreatic Adenocarcinoma

Sponsor: Actuate Therapeutics Inc.

Updated 9 times since 2021 Last updated: Nov 14, 2025 Started: Mar 21, 2022 Primary completion: Dec 31, 2025 Completion: Jul 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Pancreatic Adenocarcinoma and Pancreatic Adenocarcinoma Metastatic and is currently ongoing. Actuate Therapeutics Inc. leads this study, which shows 9 recorded versions since 2022 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Apr 2024 · 21 months · monthly snapshotRecruiting~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2025 · 13 months · monthly snapshotRecruiting~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshotActive Not Recruiting

Change History

9 versions recorded
  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  3. Sep 2024 — Oct 2025 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

Show 4 earlier versions
  1. Jul 2022 — Apr 2024 [monthly]

    Recruiting PHASE2

  2. May 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  3. Feb 2022 — May 2022 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  4. Nov 2021 — Feb 2022 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Actuate Therapeutics Inc.
  • Colin D. Weekes, M.D., PhD
  • Lustgarten Foundation
Data source: Massachusetts General Hospital

For direct contact, visit the study record on ClinicalTrials.gov .