deltatrials
Terminated PHASE2 INTERVENTIONAL 4-arm NCT05168475

Biologics in Refractory Vasculitis: A Trial of Biologic Therapy for Refractory Primary Non-ANCA Associated Vasculitis (BIOVAS)

Biologics in Refractory Vasculitis (BIOVAS): A Pragmatic, Randomised, Double-blind, Placebo-controlled, Modified-crossover Trial of Biologic Therapy for Refractory Primary Non-ANCA Associated Vasculitis in Adults and Children

Sponsor: Cambridge University Hospitals NHS Foundation Trust

Conditions Cogan Syndrome Cryoglobulinemic Vasculitis Cutaneous Polyarteritis Nodosa Giant Cell Arteritis IgA Vasculitis Polyarteritis Nodosa Primary Angiitis of Central Nervous System Relapsing Polychondritis Takayasu Arteritis
Interventions Infliximab Rituximab Tocilizumab
Updated 6 times since 2022 Last updated: May 29, 2025 Started: Jul 14, 2021 Primary completion: Nov 29, 2023 Completion: Nov 29, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

NIHR withdrawal of funding

Other terminated trials from Cambridge University Hospitals NHS Foundation Trust

See all terminations from Cambridge University Hospitals NHS Foundation Trust

This PHASE2 trial investigates Cogan Syndrome and Cryoglobulinemic Vasculitis and is currently terminated or withdrawn. Cambridge University Hospitals NHS Foundation Trust leads this study, which shows 6 recorded versions since 2021 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2022 – ~Mar 2023 · 14 months · monthly snapshotRecruiting~Mar 2023 – ~Oct 2023 · 7 months · monthly snapshotRecruiting~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshotActive Not Recruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshotActive Not Recruiting~Jul 2025 – present · 12 months · monthly snapshotTerminated

Change History

6 versions recorded

  1. Jul 2025 — Present [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

  2. Sep 2024 — Jul 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Oct 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  5. Mar 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

▶ Show 1 earlier version

  1. Jan 2022 — Mar 2023 [monthly]

    Recruiting PHASE2

    First recorded

Jul 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cambridge University Hospitals NHS Foundation Trust
Data source: Cambridge University Hospitals NHS Foundation Trust

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations