deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 2-arm NCT05222802

A Study to Evaluate ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1)

A Phase 1 Study to Evaluate the CNS-Penetrant EGFR/ERBB1 Inhibitor ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1)

Sponsor: Erasca, Inc.

Interventions ERAS-801
Updated 12 times since 2022 Last updated: Aug 13, 2025 Started: Feb 25, 2022 Primary completion: Aug 31, 2025 Completion: Sep 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Glioblastoma Multiforme and is currently ongoing. Erasca, Inc. leads this study, which shows 12 recorded versions since 2022 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshotRecruiting~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshotRecruiting~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshotRecruiting~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshotRecruiting~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshotRecruiting~Dec 2022 – ~Nov 2023 · 11 months · monthly snapshotRecruiting~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshotRecruiting~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshotActive Not Recruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotActive Not Recruiting~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshotActive Not Recruiting~Mar 2025 – ~Sep 2025 · 6 months · monthly snapshotActive Not Recruiting~Sep 2025 – present · 10 months · monthly snapshotActive Not Recruiting

Change History

12 versions recorded
  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Mar 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Feb 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

Show 7 earlier versions
  1. Nov 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

  2. Dec 2022 — Nov 2023 [monthly]

    Recruiting PHASE1

  3. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  4. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  5. Jun 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  6. Apr 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  7. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

    First recorded

Feb 2022

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Erasca, Inc.
  • Katmai Pharmaceuticals Inc.
Data source: Katmai Pharmaceuticals Inc.

For direct contact, visit the study record on ClinicalTrials.gov .