deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT05298423

Study of Pembrolizumab/Vibostolimab (MK-7684A) in Combination With Concurrent Chemoradiotherapy Followed by Pembrolizumab/Vibostolimab Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Stage III Non-small Cell Lung Cancer (MK-7684A-006) (KEYVIBE-006)

Open-label Phase 3 Study of MK-7684A (Coformulation of Vibostolimab With Pembrolizumab) in Combination With Concurrent Chemoradiotherapy Followed by MK-7684A Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Unresectable, Locally Advanced, Stage III NSCLC

Sponsor: Merck Sharp & Dohme LLC

Updated 35 times since 2022 Last updated: Jul 30, 2025 Started: May 3, 2022 Primary completion: Aug 19, 2026 Completion: Aug 19, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Carcinoma, Non-Small-Cell Lung and is currently ongoing. Merck Sharp & Dohme LLC leads this study, which shows 35 recorded versions since 2022 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Apr 2025 · 59 days · monthly snapshot~Apr 2025 – ~Aug 2025 · 4 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

35 versions recorded
  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Apr 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  5. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE3

Show 30 earlier versions
  1. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE3

  2. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE3

  3. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE3

  4. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE3

  5. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  6. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE3

  7. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

  8. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE3

  9. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE3

  10. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE3

  11. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE3

  12. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE3

  13. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE3

  14. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE3

  15. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE3

  16. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE3

  17. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE3

  18. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE3

  19. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE3

  20. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE3

  21. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE3

  22. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  23. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE3

  24. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE3

  25. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE3

  26. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  27. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  28. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  29. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  30. Apr 2022 — Jun 2022 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Merck Sharp & Dohme LLC
Data source: Merck Sharp & Dohme LLC

For direct contact, visit the study record on ClinicalTrials.gov .