deltatrials
Recruiting PHASE1 INTERVENTIONAL 4-arm NCT05338632

Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists (ROAR)

Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists - a Study in Opioid naïve Individuals and Chronic Opioid Users Under Real-life Conditions

Sponsor: Leiden University Medical Center

Updated 8 times since 2022 Last updated: Jan 29, 2025 Started: Jun 24, 2022 Primary completion: Aug 1, 2026 Completion: Oct 1, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Chronic Opioid Use and Opioid Induced Respiratory Depression and is currently actively recruiting participants. Leiden University Medical Center leads this study, which shows 8 recorded versions since 2022 — indicating limited longitudinal coverage. This study adds to the longitudinal dataset for psychiatric treatment development.

Status Flow

~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshotRecruiting~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Feb 2025 · 3 months · monthly snapshot~Feb 2025 – ~Jun 2025 · 4 months · monthly snapshot~Jun 2025 – present · 14 months · monthly snapshotRecruiting

Change History

8 versions recorded
  1. Jun 2025 — Present [monthly]

    Recruiting PHASE1

  2. Feb 2025 — Jun 2025 [monthly]

    Recruiting PHASE1

    Status: CompletedRecruiting

  3. Nov 2024 — Feb 2025 [monthly]

    Completed PHASE1

    Status: RecruitingCompleted

  4. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

Show 3 earlier versions
  1. Feb 2023 — Jul 2024 [monthly]

    Recruiting PHASE1

  2. Sep 2022 — Feb 2023 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  3. May 2022 — Sep 2022 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Leiden University Medical Center
  • U.S. Food and Drug Administration (FDA)
Data source: Leiden University Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations