deltatrials
Completed NA INTERVENTIONAL 1-arm NCT05383872

Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors

A Pivotal Study to Evaluate the Safety and Effectiveness of Exablate Model 4000 Using Microbubble Resonators to Temporarily Mediate Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors

Sponsor: InSightec

Updated 19 times since 2022 Last updated: Jul 23, 2025 Started: Aug 8, 2022 Primary completion: Feb 21, 2025 Completion: Mar 5, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Glioblastoma and Glioma and is currently completed. InSightec leads this study, which shows 19 recorded versions since 2022 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~May 2023 · 3 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Aug 2025 · 7 months · monthly snapshot~Aug 2025 – present · 13 months · monthly snapshot

Change History

19 versions recorded
  1. Aug 2025 — Present [monthly]

    Completed NA

    Status: RecruitingCompleted

  2. Jan 2025 — Aug 2025 [monthly]

    Recruiting NA

  3. Nov 2024 — Jan 2025 [monthly]

    Recruiting NA

  4. Sep 2024 — Nov 2024 [monthly]

    Recruiting NA

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting NA

Show 14 earlier versions
  1. Jun 2024 — Jul 2024 [monthly]

    Recruiting NA

  2. May 2024 — Jun 2024 [monthly]

    Recruiting NA

  3. Feb 2024 — May 2024 [monthly]

    Recruiting NA

  4. Dec 2023 — Feb 2024 [monthly]

    Recruiting NA

  5. Oct 2023 — Dec 2023 [monthly]

    Recruiting NA

  6. Sep 2023 — Oct 2023 [monthly]

    Recruiting NA

  7. Aug 2023 — Sep 2023 [monthly]

    Recruiting NA

  8. Jul 2023 — Aug 2023 [monthly]

    Recruiting NA

  9. Jun 2023 — Jul 2023 [monthly]

    Recruiting NA

  10. May 2023 — Jun 2023 [monthly]

    Recruiting NA

  11. Feb 2023 — May 2023 [monthly]

    Recruiting NA

  12. Nov 2022 — Feb 2023 [monthly]

    Recruiting NA

  13. Sep 2022 — Nov 2022 [monthly]

    Recruiting NA

    Status: Not Yet RecruitingRecruiting

  14. Jun 2022 — Sep 2022 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • InSightec
Data source: InSightec

For direct contact, visit the study record on ClinicalTrials.gov .