deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT05436990

Antitumor Activity of Vactosertib in Combination With Pembrolizumab in Acral and Mucosal Melanoma Patients Progressed From Prior Immune Check Point Inhibitor

A Phase II Multicenter Study to Assess the Antitumor Activity of Vactosertib in Combination With Pembrolizumab in Acral and Mucosal Melanoma Patients Progressed From Prior Immune Check Point Inhibitor

Sponsor: Yonsei University

Updated 5 times since 2022 Last updated: Mar 27, 2025 Started: Feb 9, 2023 Primary completion: Mar 10, 2025 Completion: Mar 10, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

According to the protocol criteria, during the Phase 1 analysis, the registered participants' imaging evaluation responses did not meet the criteria, leading to an early termination

This PHASE2 trial investigates Acral Melanoma and Mucosal Melanoma and is currently terminated or withdrawn. Yonsei University leads this study, which shows 5 recorded versions since 2023 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jul 2022 – ~Jul 2024 · 24 months · monthly snapshotNot Yet Recruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshotNot Yet Recruiting~May 2025 – ~Sep 2025 · 4 months · monthly snapshotTerminated~Sep 2025 – present · 10 months · monthly snapshotTerminated

Change History

5 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. May 2025 — Sep 2025 [monthly]

    Terminated PHASE2

    Status: Not Yet RecruitingTerminated

  3. Sep 2024 — May 2025 [monthly]

    Not Yet Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Not Yet Recruiting PHASE2

  5. Jul 2022 — Jul 2024 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Yonsei University
Data source: Yonsei University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations