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Completed INTERVENTIONAL NCT05445427

Vagal Nerve Stimulation for Post COVID Fatigue

Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study

Sponsor: Mayo Clinic

Updated 10 times since 2022 Last updated: Apr 22, 2026 Started: Dec 21, 2022 Primary completion: Mar 28, 2024 Completion: Mar 28, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A observational or N/A phase clinical study on Fatigue and Headache, this trial is completed. The trial is conducted by Mayo Clinic and has accumulated 10 data snapshots since 2022. Infectious disease trials contribute critical data for public health response and treatment development.

Study Description(click to expand)

Patients, after consenting, will perform questionnaires, have a blood samples taken, and undergo PET/CT scans of the brain. Patients will then be randomized to either receive vagal nerve stimulation, or continue standard clinical care. For those randomized to receive treatment, they will be given a device and asked to follow a specific regimen daily for 12 weeks.

Patients, after consenting, will perform questionnaires, have a blood samples taken, and undergo PET/CT scans of the brain. Patients will then be randomized to either receive vagal nerve stimulation, or continue standard clinical care. For those randomized to receive treatment, they will be given a device and asked to follow a specific regimen daily for 12 weeks.

Status Flow

~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Jan 2023 · 2 months · monthly snapshot~Jan 2023 – ~Mar 2023 · 59 days · monthly snapshot~Mar 2023 – ~May 2024 · 14 months · monthly snapshotRecruiting~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Apr 2025 · 5 months · monthly snapshotCompleted~Apr 2025 – ~Apr 2026 · 13 months · monthly snapshotCompletedApr 28, 2026 – present · 2 months · daily API

Change History

10 versions recorded
  1. Apr 28, 2026 — Present [daily]

    Completed

    Phase: NANone

  2. Apr 2025 — Apr 2026 [monthly]

    Completed NA

  3. Nov 2024 — Apr 2025 [monthly]

    Completed NA

  4. Sep 2024 — Nov 2024 [monthly]

    Completed NA

  5. Jul 2024 — Sep 2024 [monthly]

    Completed NA

Show 5 earlier versions
  1. May 2024 — Jul 2024 [monthly]

    Completed NA

    Status: RecruitingCompleted

  2. Mar 2023 — May 2024 [monthly]

    Recruiting NA

  3. Jan 2023 — Mar 2023 [monthly]

    Recruiting NA

    Status: Not Yet RecruitingRecruiting

  4. Nov 2022 — Jan 2023 [monthly]

    Not Yet Recruiting NA

  5. Sep 2022 — Nov 2022 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

The purpose of this study is to evaluate the impact of vagal nerve stimulation on patients with post COVID syndrome who have fatigue and headache.

Contact Information

Sponsor contact:
  • Mayo Clinic
Data source: ClinicalTrials.gov

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations