deltatrials
Completed PHASE2 NCT05510895

Neoadjuvant Encorafenib, Binimetinib and Cetuximab for Patients With BRAF V600E Mutated/pMMR Localized Colorectal Cancer

Sponsor: AIO-Studien-gGmbH

Interventions Binimetinib
Updated 6 times since 2022 Last updated: Sep 30, 2025 Started: Sep 1, 2022 Primary completion: Jul 31, 2024 Completion: Jan 31, 2025

This PHASE2 trial investigates BRAF V600 Mutation and BRAF V600E and is currently completed. AIO-Studien-gGmbH leads this study, which shows 6 recorded versions since 2022 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Sep 2022 – ~Jul 2023 · 10 months · monthly snapshotNot Yet Recruiting~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshotRecruiting~Jul 2025 – ~Nov 2025 · 4 months · monthly snapshotUnknown~Nov 2025 – present · 5 months · monthly snapshotCompleted

Change History

6 versions recorded
  1. Nov 2025 — Present [monthly]

    Completed PHASE2

    Status: UnknownCompleted

  2. Jul 2025 — Nov 2025 [monthly]

    Unknown PHASE2

    Status: RecruitingUnknown

  3. Sep 2024 — Jul 2025 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Jul 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

Show 1 earlier version
  1. Sep 2022 — Jul 2023 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AIO-Studien-gGmbH
  • Merck Serono GmbH, Germany
  • Pierre Fabre Pharma GmbH
  • Universitätsklinikum Hamburg-Eppendorf
Data source: AIO-Studien-gGmbH

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations