Recruiting PHASE2/PHASE3 INTERVENTIONAL 2-arm NCT05535738

Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation

Biologics and Blistering - Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation Through Suction Blistering

Sponsor: Wei-Che Ko

Conditions Allergic Contact Dermatitis Skin Inflammation

Interventions Adalimumab Betamethasone Valerate Canakinumab Dupilumab Fluticasone Propionate Guselkumab Known patch test allergens Microneedle Sarilumab Skin punch biopsy Squaric Acid Dibutyl Ester Suction blistering Triamcinolone Acetonide Ustekinumab

Updated 8 times since 2022 Last updated: Nov 12, 2025 Started: Nov 15, 2022 Primary completion: Jan 1, 2027 Completion: Dec 31, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2/PHASE3 trial investigates Allergic Contact Dermatitis and Skin Inflammation and is currently actively recruiting participants. Wei-Che Ko leads this study, which shows 8 recorded versions since 2022 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

8 versions recorded

Dec 2025 — Present [monthly]

Recruiting PHASE2/PHASE3
Nov 2025 — Dec 2025 [monthly]

Recruiting PHASE2/PHASE3
Jul 2025 — Nov 2025 [monthly]

Recruiting PHASE2/PHASE3
Sep 2024 — Jul 2025 [monthly]

Recruiting PHASE2/PHASE3
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE2/PHASE3

Phase: PHASE2_PHASE3 → PHASE2/PHASE3

▶ Show 3 earlier versions

Jun 2024 — Jul 2024 [monthly]

Recruiting PHASE2_PHASE3
Jul 2023 — Jun 2024 [monthly]

Recruiting PHASE2_PHASE3
Sep 2022 — Jul 2023 [monthly]

Recruiting PHASE2_PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Wei-Che Ko

Data source: University of Massachusetts, Worcester

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Worcester, United States