deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT05536037

Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

Metformin Chemoprevention of Oral Premalignant Lesions

Sponsor: Thomas Jefferson University

Interventions Biopsy Metformin
Updated 8 times since 2022 Last updated: May 14, 2025 Started: May 4, 2022 Primary completion: Mar 16, 2024 Completion: Mar 16, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Slow accrual

Listed as NCT05536037, this PHASE1 trial focuses on Erythroplakia and Leukoplakia and remains terminated or withdrawn. Sponsored by Thomas Jefferson University, it has been updated 8 times since 2022, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshotRecruiting~Jan 2023 – ~Feb 2024 · 13 months · monthly snapshotRecruiting~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshotActive Not Recruiting~Apr 2024 – ~May 2024 · 30 days · monthly snapshotActive Not Recruiting~May 2024 – ~Jul 2024 · 2 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshotTerminated~Jun 2025 – present · 13 months · monthly snapshotTerminated

Change History

8 versions recorded
  1. Jun 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2024 — Jun 2025 [monthly]

    Terminated PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  4. May 2024 — Jul 2024 [monthly]

    Terminated PHASE1

    Status: Active Not RecruitingTerminated

  5. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

Show 3 earlier versions
  1. Feb 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  2. Jan 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

  3. Sep 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

    First recorded

May 2022

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Thomas Jefferson University
Data source: Thomas Jefferson University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations