deltatrials
Completed PHASE2 INTERVENTIONAL 4-arm NCT05546476

Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 (PROACC-1)

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY, SAFETY AND TOLERABILITY OF PONSEGROMAB IN PATIENTS WITH CANCER, CACHEXIA, AND ELEVATED CONCENTRATIONS OF GDF-15, FOLLOWED BY AN OPTIONAL OPEN-LABEL TREATMENT PERIOD (PROACC -1)

Sponsor: Pfizer

Updated 27 times since 2022 Last updated: May 29, 2025 Started: Nov 21, 2022 Primary completion: Mar 13, 2024 Completion: Apr 23, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Cachexia and Colorectal Cancer, this trial is completed. The trial is conducted by Pfizer and has accumulated 27 data snapshots since 2022. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Sep 2022 – ~Oct 2022 · 30 days · monthly snapshot~Oct 2022 – ~Nov 2022 · 31 days · monthly snapshot~Nov 2022 – ~Jan 2023 · 2 months · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 6 months · monthly snapshot

Change History

27 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE2

  3. Jun 2025 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  4. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE2

Show 22 earlier versions
  1. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  4. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Jan 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  8. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  9. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE2

  10. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  11. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  12. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  13. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  14. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  15. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  16. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  17. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  18. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  19. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  20. Nov 2022 — Jan 2023 [monthly]

    Not Yet Recruiting PHASE2

  21. Oct 2022 — Nov 2022 [monthly]

    Not Yet Recruiting PHASE2

  22. Sep 2022 — Oct 2022 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Pfizer
Data source: Pfizer

For direct contact, visit the study record on ClinicalTrials.gov .