Completed PHASE2/PHASE3 INTERVENTIONAL 3-arm NCT05560919

Acceleration of Orthodontic Tooth Movement

Evaluation of Clinical Efficacy of Locally Injected Vitamin D3 (Calcitriol or 1,25 Dihidroxicolecalciferol) in Accelerating Orthodontic Tooth Movement (A Randomized Controlled Trial)

Sponsor: Tishreen University

Conditions Mild to Moderate Anterior Mandibular Segment Crowdind

Interventions Dihydroxycholecalciferols dimethyl sulfoxide serum

Updated 4 times since 2022 Last updated: Sep 26, 2022 Started: Sep 20, 2021 Primary completion: Apr 30, 2022 Completion: Jun 25, 2022

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05560919, this PHASE2/PHASE3 trial focuses on Mild to Moderate Anterior Mandibular Segment Crowdind and remains completed. Sponsored by Tishreen University, it has been updated 4 times since 2021, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

4 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2/PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2/PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2/PHASE3

Phase: PHASE2_PHASE3 → PHASE2/PHASE3
Oct 2022 — Jul 2024 [monthly]

Completed PHASE2_PHASE3

First recorded

Sep 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Tishreen University

Data source: Tishreen University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Latakia, Syria