Completed PHASE4 INTERVENTIONAL 2-arm NCT05575700

Safety of Ibuprofen After Major Orthopaedic Surgeries (PERISAFE)

Safety of Ibuprofen After Major Orthopaedic Surgeries. The PERISAFE Randomized Clinical Multicentre Trial

Sponsor: Naestved Hospital

Conditions Analgesia Analgesic Adverse Reaction Hip Arthropathy Knee Arthropathy Pain, Acute Postoperative Complications Postoperative Pain Safety Issues

Interventions Ibuprofen Placebo

Updated 6 times since 2022 Last updated: Dec 12, 2025 Started: Apr 17, 2023 Primary completion: Aug 19, 2025 Completion: Aug 19, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05575700, this PHASE4 trial focuses on Analgesia and Analgesic Adverse Reaction and remains completed. Sponsored by Naestved Hospital, it has been updated 6 times since 2023, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

6 versions recorded

Jan 2026 — Present [monthly]

Completed PHASE4

Status: Recruiting → Completed
Sep 2024 — Jan 2026 [monthly]

Recruiting PHASE4
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE4
May 2023 — Jul 2024 [monthly]

Recruiting PHASE4

Status: Not Yet Recruiting → Recruiting
Dec 2022 — May 2023 [monthly]

Not Yet Recruiting PHASE4

▶ Show 1 earlier version

Nov 2022 — Dec 2022 [monthly]

Not Yet Recruiting PHASE4

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Naestved Hospital

Data source: Naestved Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Brøndby, Denmark , Copenhagen NV, Denmark , Farsø, Denmark , Hellerup, Denmark , Hillerød, Denmark , Køge, Denmark , Næstved, Denmark , Odense, Denmark , Silkeborg, Denmark , Svendborg, Denmark and 1 more location