deltatrials
Recruiting PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT05586581

SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy (ART)

PET Imaging of Synaptic Density Combined With Neuroimmunologic Measures to Reveal Mechanisms of HIV Neuropathogenesis During ART

Sponsor: National Institute of Mental Health (NIMH)

Updated 7 times since 2022 Last updated: Sep 2, 2025 Started: May 17, 2023 Primary completion: Dec 31, 2027 Completion: Dec 31, 2030
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05586581, this PHASE1/PHASE2 trial focuses on HIV Associated Neurocognitive Disorder and HIV Dementia and remains actively recruiting participants. Sponsored by National Institute of Mental Health (NIMH), it has been updated 7 times since 2023, reflecting limited change activity. This study is part of the global effort to build evidence for infectious disease interventions.

Status Flow

~Nov 2022 – ~May 2023 · 6 months · monthly snapshotNot Yet Recruiting~May 2023 – ~Jul 2023 · 2 months · monthly snapshotNot Yet Recruiting~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshotRecruiting~Oct 2024 – ~Oct 2025 · 12 months · monthly snapshotRecruiting~Oct 2025 – present · 9 months · monthly snapshotRecruiting

Change History

7 versions recorded
  1. Oct 2025 — Present [monthly]

    Recruiting PHASE1/PHASE2

  2. Oct 2024 — Oct 2025 [monthly]

    Recruiting PHASE1/PHASE2

  3. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1/PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  5. Jul 2023 — Jul 2024 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet RecruitingRecruiting

Show 2 earlier versions
  1. May 2023 — Jul 2023 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  2. Nov 2022 — May 2023 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Mental Health (NIMH)
  • National Institutes of Health (NIH)
  • Yale University
Data source: Yale University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations