Active Not Recruiting PHASE1/PHASE2 INTERVENTIONAL 5-arm NCT05660408

RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors (RNA PRIME)

RNA PRIME - RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors

Sponsor: Alex's Lemonade Stand Foundation

Conditions Recurrent High-grade Glioma Recurrent Pulmonary Osteosarcoma

Interventions Surgical Biopsy/Resection pp65 RNA LP (DP1) pp65/tumor mRNA RNA-LP (DP2)

Updated 18 times since 2023 Last updated: Mar 6, 2026 Started: Mar 12, 2025 Primary completion: Oct 31, 2033 Completion: Oct 31, 2035

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05660408, this PHASE1/PHASE2 trial focuses on Recurrent High-grade Glioma and Recurrent Pulmonary Osteosarcoma and remains ongoing. Sponsored by Alex's Lemonade Stand Foundation, it has been updated 18 times since 2025, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

18 versions recorded

Mar 2026 — Present [monthly]

Active Not Recruiting PHASE1/PHASE2

Status: Recruiting → Active Not Recruiting
Feb 2026 — Mar 2026 [monthly]

Recruiting PHASE1/PHASE2
Oct 2025 — Feb 2026 [monthly]

Recruiting PHASE1/PHASE2

Status: Active Not Recruiting → Recruiting
Sep 2025 — Oct 2025 [monthly]

Active Not Recruiting PHASE1/PHASE2
Jun 2025 — Sep 2025 [monthly]

Active Not Recruiting PHASE1/PHASE2

Status: Recruiting → Active Not Recruiting

▶ Show 13 earlier versions

May 2025 — Jun 2025 [monthly]

Recruiting PHASE1/PHASE2
Apr 2025 — May 2025 [monthly]

Recruiting PHASE1/PHASE2

Status: Not Yet Recruiting → Recruiting
Mar 2025 — Apr 2025 [monthly]

Not Yet Recruiting PHASE1/PHASE2
Feb 2025 — Mar 2025 [monthly]

Not Yet Recruiting PHASE1/PHASE2
Dec 2024 — Feb 2025 [monthly]

Not Yet Recruiting PHASE1/PHASE2

Phase: PHASE1 → PHASE1/PHASE2
Nov 2024 — Dec 2024 [monthly]

Not Yet Recruiting PHASE1

Phase: PHASE1/PHASE2 → PHASE1
Oct 2024 — Nov 2024 [monthly]

Not Yet Recruiting PHASE1/PHASE2
Sep 2024 — Oct 2024 [monthly]

Not Yet Recruiting PHASE1/PHASE2
Jul 2024 — Sep 2024 [monthly]

Not Yet Recruiting PHASE1/PHASE2

Phase: PHASE1_PHASE2 → PHASE1/PHASE2
May 2024 — Jul 2024 [monthly]

Not Yet Recruiting PHASE1_PHASE2
Dec 2023 — May 2024 [monthly]

Not Yet Recruiting PHASE1_PHASE2
Feb 2023 — Dec 2023 [monthly]

Not Yet Recruiting PHASE1_PHASE2
Jan 2023 — Feb 2023 [monthly]

Not Yet Recruiting PHASE1_PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Alex's Lemonade Stand Foundation
National Cancer Institute (NCI)
National Pediatric Cancer Foundation
The Osteosarcoma Institute
The V Foundation for Cancer Research
University of Florida

Data source: University of Florida

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Gainesville, United States