deltatrials
Recruiting PHASE1 INTERVENTIONAL 1-arm NCT05679895

Safety and Efficacy of OC-1 Therapy in Patients With R/R T-ALL/LL (CARxALL)

Safety and Efficacy of hCD1a-CAR T (OC-1) Therapy, in Patients With Relapsed/Refractory (R/R) T-cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL/LL

Sponsor: Astrum CRO, S.L.

Interventions CD1a-CAR T
Updated 7 times since 2023 Last updated: Mar 9, 2026 Started: Jan 31, 2023 Primary completion: Dec 31, 2027 Completion: Dec 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Lymphoblastic T-Cell Lymphoma and T-cell Acute Lymphoblastic Leukemia, this trial is actively recruiting participants. The trial is conducted by Astrum CRO, S.L. and has accumulated 7 data snapshots since 2023. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshotNot Yet Recruiting~Mar 2023 – ~May 2024 · 14 months · monthly snapshotRecruiting~May 2024 – ~Jul 2024 · 2 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotRecruiting~Sep 2025 – ~Mar 2026 · 6 months · monthly snapshotRecruiting~Mar 2026 – present · 4 months · monthly snapshotRecruiting

Change History

7 versions recorded
  1. Mar 2026 — Present [monthly]

    Recruiting PHASE1

  2. Sep 2025 — Mar 2026 [monthly]

    Recruiting PHASE1

  3. Sep 2024 — Sep 2025 [monthly]

    Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  5. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

Show 2 earlier versions
  1. Mar 2023 — May 2024 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  2. Feb 2023 — Mar 2023 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Jan 2023

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Astrum CRO, S.L.
  • BioClever 2005 S.L.
  • Hospital Clinic of Barcelona
  • Hospital Sant Joan de Deu
  • OneChain Immunotherapeutics
Data source: OneChain Immunotherapeutics

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations