Recruiting PHASE3 INTERVENTIONAL 2-arm NCT05699174

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation (POvIV2)

PO Versus IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

Sponsor: Major Extremity Trauma Research Consortium

Conditions Amputation Antibiotic Side Effect Fracture Infected Wound Infections Injury Leg Internal Fixation; Complications, Infection or Inflammation Lower Extremity Fracture Nonunion of Fracture

Interventions Standard of Care Intravenous (IV) antibiotics Standard of Care PO (oral) antibiotics

Updated 7 times since 2023 Last updated: Jan 29, 2026 Started: May 30, 2023 Primary completion: Sep 30, 2026 Completion: Sep 29, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05699174, this PHASE3 trial focuses on Amputation and Antibiotic Side Effect and remains actively recruiting participants. Sponsored by Major Extremity Trauma Research Consortium, it has been updated 7 times since 2023, reflecting limited change activity. This study is part of the global effort to build evidence for infectious disease interventions.

Status Flow

Change History

7 versions recorded

Feb 2026 — Present [monthly]

Recruiting PHASE3
Sep 2025 — Feb 2026 [monthly]

Recruiting PHASE3
Jun 2025 — Sep 2025 [monthly]

Recruiting PHASE3
Sep 2024 — Jun 2025 [monthly]

Recruiting PHASE3
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE3

▶ Show 2 earlier versions

Apr 2024 — Jul 2024 [monthly]

Recruiting PHASE3

Status: Not Yet Recruiting → Recruiting
Feb 2023 — Apr 2024 [monthly]

Not Yet Recruiting PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Major Extremity Trauma Research Consortium
United States Department of Defense

Data source: Major Extremity Trauma Research Consortium

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baltimore, United States , Charlotte, United States , Hershey, United States , Houston, United States , Indianapolis, United States , Madison, United States , Minneapolis, United States , Nashville, United States , Oklahoma City, United States , Queens, United States and 2 more locations