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Terminated PHASE1 INTERVENTIONAL 1-arm NCT05712278

A Study to Investigate Use of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in Relapsed/Refractory Acute Myeloid Leukemia

A Phase I, Single-arm, Open Label, Dose Escalation, Multicenter Study of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML)

Sponsor: Sanofi

Updated 13 times since 2023 Last updated: Sep 8, 2025 Started: Jun 16, 2023 Primary completion: Feb 23, 2024 Completion: Mar 12, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

This trial was terminated. No reason was provided.

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Listed as NCT05712278, this PHASE1 trial focuses on Acute Myeloid Leukaemia and remains terminated or withdrawn. Sponsored by Sanofi, it has been updated 13 times since 2023, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Dec 2023 · 4 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 11 months · monthly snapshot

Change History

13 versions recorded
  1. Oct 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2025 — Oct 2025 [monthly]

    Terminated PHASE1

  3. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  5. May 2024 — Jul 2024 [monthly]

    Terminated PHASE1

    Status: Active Not RecruitingTerminated

Show 8 earlier versions
  1. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  3. Jan 2024 — Mar 2024 [monthly]

    Recruiting PHASE1

  4. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE1

  5. Aug 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  6. May 2023 — Aug 2023 [monthly]

    Not Yet Recruiting PHASE1

  7. Apr 2023 — May 2023 [monthly]

    Not Yet Recruiting PHASE1

  8. Mar 2023 — Apr 2023 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Sanofi
Data source: Sanofi

For direct contact, visit the study record on ClinicalTrials.gov .