Recruiting PHASE1 INTERVENTIONAL 1-arm NCT05733689

Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial)

Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial) - a Phase Ib Feasibility Trial

Sponsor: BillionToOne, Inc

Conditions Gastroesophageal Adenocarcinoma

Interventions DOCETAXEL and IRINOTECAN (alone or combined) Durvalumab FLOT FOLFIRI FOLFIRINOX FOLFOX NIVOLUMAB (alone or when added to a regimen above) PACLITAXEL with or without CARBOPLATIN PEMBROLIZUMAB (alone or when added to a regimen above) Trastuzumab

Updated 10 times since 2023 Last updated: Mar 6, 2026 Started: Jun 27, 2025 Primary completion: Jun 30, 2027 Completion: Jun 30, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05733689, this PHASE1 trial focuses on Gastroesophageal Adenocarcinoma and remains actively recruiting participants. Sponsored by BillionToOne, Inc, it has been updated 10 times since 2025, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

10 versions recorded

Mar 2026 — Present [monthly]

Recruiting PHASE1
Sep 2025 — Mar 2026 [monthly]

Recruiting PHASE1
Aug 2025 — Sep 2025 [monthly]

Recruiting PHASE1

Status: Not Yet Recruiting → Recruiting
May 2025 — Aug 2025 [monthly]

Not Yet Recruiting PHASE1
Sep 2024 — May 2025 [monthly]

Not Yet Recruiting PHASE1

▶ Show 5 earlier versions

Jul 2024 — Sep 2024 [monthly]

Not Yet Recruiting PHASE1
Mar 2024 — Jul 2024 [monthly]

Not Yet Recruiting PHASE1
Jul 2023 — Mar 2024 [monthly]

Not Yet Recruiting PHASE1
Apr 2023 — Jul 2023 [monthly]

Not Yet Recruiting PHASE1
Mar 2023 — Apr 2023 [monthly]

Not Yet Recruiting PHASE1

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

BillionToOne, Inc
University of California, Irvine

Data source: University of California, Irvine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Orange, United States