Recruiting NA INTERVENTIONAL 2-arm NCT05831085

Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease (DEFINE-DM)

A Comparison of Imaging- and Physiology-Guided State-of-the-Art Percutaneous Coronary Intervention and Coronary-Artery Bypass Grafting in Patients With Diabetes and Three-Vessel Coronary Artery Disease: DEFINE-DM Trial (Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease)

Sponsor: CardioVascular Research Foundation, Korea

Conditions Coronary Artery Stenosis

Interventions State-of-the-Art Percutaneous Coronary Intervention standard CABG

Updated 11 times since 2023 Last updated: Dec 23, 2025 Started: Jun 14, 2024 Primary completion: Jun 30, 2027 Completion: Dec 31, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Coronary Artery Stenosis and is currently actively recruiting participants. CardioVascular Research Foundation, Korea leads this study, which shows 11 recorded versions since 2024 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

Change History

11 versions recorded

Jan 2026 — Present [monthly]

Recruiting NA
Dec 2025 — Jan 2026 [monthly]

Recruiting NA
Sep 2025 — Dec 2025 [monthly]

Recruiting NA
Jul 2025 — Sep 2025 [monthly]

Recruiting NA
Sep 2024 — Jul 2025 [monthly]

Recruiting NA

▶ Show 6 earlier versions

Aug 2024 — Sep 2024 [monthly]

Recruiting NA

Phase: PHASE4 → NA
Jul 2024 — Aug 2024 [monthly]

Recruiting PHASE4

Status: Not Yet Recruiting → Recruiting
Mar 2024 — Jul 2024 [monthly]

Not Yet Recruiting PHASE4
Jan 2024 — Mar 2024 [monthly]

Not Yet Recruiting PHASE4
Oct 2023 — Jan 2024 [monthly]

Not Yet Recruiting PHASE4
May 2023 — Oct 2023 [monthly]

Not Yet Recruiting PHASE4

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

CardioVascular Research Foundation, Korea
Duk-Woo Park, MD

Data source: Asan Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Bangkok, Thailand , Beijing, China , Belgrade, Serbia , Daegu, South Korea , Daejeon, South Korea , Gangneung, South Korea , Gurugram, India , Gwangju, South Korea , Hanzhou, China , Ilsan, South Korea and 11 more locations