A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
A Phase 1, Multicenter, Open-Label Study Of CC-97540 (BMS-986353), CD19-Targeted Nex-T Chimeric Antigen Receptor (CAR) T Cells, in Participants With Severe, Refractory Autoimmune Diseases: Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy, Systemic Sclerosis, or Rheumatoid Arthritis (Breakfree-1)
Sponsor: Bristol-Myers Squibb Services Unlimited Company
Listed as NCT05869955, this PHASE1 trial focuses on Idiopathic Inflammatory Myopathy and Rheumatoid Arthritis and remains actively recruiting participants. Sponsored by Bristol-Myers Squibb Services Unlimited Company, it has been updated 29 times since 2023, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
29 versions recorded-
Feb 2026 — Present [monthly]
Recruiting PHASE1
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Jan 2026 — Feb 2026 [monthly]
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▶ Show 24 earlier versions
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Jul 2025 — Sep 2025 [monthly]
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May 2025 — Jun 2025 [monthly]
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Apr 2025 — May 2025 [monthly]
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Mar 2025 — Apr 2025 [monthly]
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Feb 2025 — Mar 2025 [monthly]
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Jan 2025 — Feb 2025 [monthly]
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Dec 2024 — Jan 2025 [monthly]
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Nov 2024 — Dec 2024 [monthly]
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Sep 2024 — Nov 2024 [monthly]
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Aug 2024 — Sep 2024 [monthly]
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Jul 2024 — Aug 2024 [monthly]
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Jun 2024 — Jul 2024 [monthly]
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May 2024 — Jun 2024 [monthly]
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Apr 2024 — May 2024 [monthly]
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Mar 2024 — Apr 2024 [monthly]
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Feb 2024 — Mar 2024 [monthly]
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Jan 2024 — Feb 2024 [monthly]
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Dec 2023 — Jan 2024 [monthly]
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Nov 2023 — Dec 2023 [monthly]
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Oct 2023 — Nov 2023 [monthly]
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Aug 2023 — Oct 2023 [monthly]
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Status: Not Yet Recruiting → Recruiting
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Jul 2023 — Aug 2023 [monthly]
Not Yet Recruiting PHASE1
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Jun 2023 — Jul 2023 [monthly]
Not Yet Recruiting PHASE1
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Bristol-Myers Squibb Services Unlimited Company
- Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
For direct contact, visit the study record on ClinicalTrials.gov .