Unknown PHASE2 INTERVENTIONAL 4-arm NCT05906563

Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects

Clinical and Radiographic Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects: A Randomized Controlled Clinical Trial

Sponsor: Amira ragab

Conditions Bone Loss in Jaw

Interventions Melatonin gel Metformin and melatonin gel placebo gel scaling and root planning

Updated 5 times since 2023 Last updated: Jun 13, 2023 Started: Dec 14, 2022 Primary completion: May 31, 2024 Completion: Jun 30, 2024

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Bone Loss in Jaw, this trial is ongoing. The trial is conducted by Amira ragab and has accumulated 5 data snapshots since 2022. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

5 versions recorded

Sep 2025 — Present [monthly]

Unknown PHASE2
Jun 2025 — Sep 2025 [monthly]

Unknown PHASE2

Status: Enrolling By Invitation → Unknown
Sep 2024 — Jun 2025 [monthly]

Enrolling By Invitation PHASE2
Jul 2024 — Sep 2024 [monthly]

Enrolling By Invitation PHASE2
Jul 2023 — Jul 2024 [monthly]

Enrolling By Invitation PHASE2

First recorded

Dec 2022

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Amira ragab

Data source: Mansoura University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Al Mansurah, Egypt