Recruiting PHASE2 INTERVENTIONAL 2-arm NCT05957848

Guanfacine Extended-release for Adolescents With Cannabis Use (GRACE)

Guanfacine Extended-release Randomised Controlled Trial for Adolescents With Cannabis usE (GRACE)

Sponsor: Orygen

Interventions Engagement with alcohol and other drug services Guanfacine Extended Release Oral Tablet Placebo Residential withdrawal

Updated 5 times since 2023 Last updated: Jul 29, 2025 Started: Jul 27, 2023 Primary completion: Dec 31, 2025 Completion: Jun 30, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Cannabis Use Disorder, this trial is actively recruiting participants. The trial is conducted by Orygen and has accumulated 5 data snapshots since 2023. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

5 versions recorded

Aug 2025 — Present [monthly]

Recruiting PHASE2
Sep 2024 — Aug 2025 [monthly]

Recruiting PHASE2
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE2
Sep 2023 — Jul 2024 [monthly]

Recruiting PHASE2

Status: Not Yet Recruiting → Recruiting
Aug 2023 — Sep 2023 [monthly]

Not Yet Recruiting PHASE2

First recorded

Jul 2023

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Orygen
University of Melbourne
Youth Support and Advocacy Service

Data source: Orygen

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Parkville, Australia