Active Not Recruiting PHASE2 INTERVENTIONAL 5-arm NCT06058299

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, with Pretomanid and Linezolid in Adults with Drug-sensitive Pulmonary Tuberculosis

A Phase 2, Partially-blinded, Randomised Trial Assessing the Safety and Efficacy of TBAJ-876 or Bedaquiline, in Combination with Pretomanid and Linezolid in Adult Participants with Newly Diagnosed, Drug-sensitive, Smear-positive Pulmonary Tuberculosis

Sponsor: Global Alliance for TB Drug Development

Conditions Drug Sensitive Tuberculosis Pulmonary TB Pulmonary Tuberculosis

Interventions Bedaquiline HR HRZE Linezolid Pretomanid TBAJ-876

Updated 7 times since 2023 Last updated: Feb 13, 2025 Started: Oct 24, 2023 Primary completion: Dec 27, 2024 Completion: Jun 30, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Drug Sensitive Tuberculosis and Pulmonary TB and is currently ongoing. Global Alliance for TB Drug Development leads this study, which shows 7 recorded versions since 2023 — indicating limited longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

Change History

7 versions recorded

Mar 2025 — Present [monthly]

Active Not Recruiting PHASE2
Oct 2024 — Mar 2025 [monthly]

Active Not Recruiting PHASE2

Status: Recruiting → Active Not Recruiting
Sep 2024 — Oct 2024 [monthly]

Recruiting PHASE2
Aug 2024 — Sep 2024 [monthly]

Recruiting PHASE2
Jul 2024 — Aug 2024 [monthly]

Recruiting PHASE2

▶ Show 2 earlier versions

Apr 2024 — Jul 2024 [monthly]

Recruiting PHASE2

Status: Not Yet Recruiting → Recruiting
Oct 2023 — Apr 2024 [monthly]

Not Yet Recruiting PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Global Alliance for TB Drug Development

Data source: Global Alliance for TB Drug Development

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Brits, South Africa , Cape Town, South Africa , Dasmariñas, Philippines , Durban, South Africa , East London, South Africa , George, South Africa , Hillcrest, South Africa , Johannesburg, South Africa , Kampala, Uganda , Klerksdorp, South Africa and 9 more locations