Optimal Stimulation Parameters to Disrupt Epileptiform Activity
Optimal Stimulation Parameters for Spike-ripple Disruption in Patients Undergoing Invasive Monitoring
Sponsor: Boston University
Listed as NCT06141668, this observational or N/A phase trial focuses on Refractory Epilepsy and remains completed. Sponsored by Boston University, it has been updated 5 times since 2023, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
5 versions recorded-
May 4, 2026 — Present [daily]
Completed
Status: Recruiting → Completed · Phase: NA → None
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Dec 2024 — May 2026 [monthly]
Recruiting NA
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Sep 2024 — Dec 2024 [monthly]
Recruiting NA
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Jul 2024 — Sep 2024 [monthly]
Recruiting NA
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Dec 2023 — Jul 2024 [monthly]
Recruiting NA
First recorded
Jun 2023
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.
Contact Information
- Boston University
- Massachusetts General Hospital
- National Institute of Neurological Disorders and Stroke (NINDS)
For direct contact, visit the study record on ClinicalTrials.gov .