Completed NA INTERVENTIONAL 2-arm NCT06180460

CALM: Managing Distress in Malignant Brain Cancer

Managing Distress in Malignant Brain Cancer - Phase IIc RCT

Sponsor: United States Department of Defense

Conditions Brain Cancer Brain Metastases Brain Tumor Metastatic Breast Cancer Metastatic Colon Cancer Metastatic Kidney Cancer Metastatic Lung Cancer Metastatic Melanoma

Interventions CALM Treatment as usual

Updated 9 times since 2024 Last updated: Oct 2, 2025 Started: Nov 10, 2023 Primary completion: Sep 30, 2025 Completion: Sep 30, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A NA clinical study on Brain Cancer and Brain Metastases, this trial is completed. The trial is conducted by United States Department of Defense and has accumulated 9 data snapshots since 2023. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

9 versions recorded

Nov 2025 — Present [monthly]

Completed NA

Status: Active Not Recruiting → Completed
Jun 2025 — Nov 2025 [monthly]

Active Not Recruiting NA
Apr 2025 — Jun 2025 [monthly]

Active Not Recruiting NA

Status: Recruiting → Active Not Recruiting
Mar 2025 — Apr 2025 [monthly]

Recruiting NA
Sep 2024 — Mar 2025 [monthly]

Recruiting NA

▶ Show 4 earlier versions

Jul 2024 — Sep 2024 [monthly]

Recruiting NA
Mar 2024 — Jul 2024 [monthly]

Recruiting NA
Feb 2024 — Mar 2024 [monthly]

Recruiting NA
Jan 2024 — Feb 2024 [monthly]

Recruiting NA

First recorded

Nov 2023

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

United States Department of Defense
Virginia Commonwealth University

Data source: Virginia Commonwealth University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Richmond, United States