Parasitic Ulcer Treatment Trial (PUTT)
Sponsor: Aravind Eye Care System
A observational or N/A phase clinical study on Acanthamoeba Keratitis, this trial is actively recruiting participants. The trial is conducted by Aravind Eye Care System and has accumulated 11 data snapshots since 2024. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.
Status Flow
Change History
11 versions recorded-
May 4, 2026 — Present [daily]
Recruiting
Phase: PHASE3 → None
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Feb 2026 — May 2026 [monthly]
Recruiting PHASE3
-
Nov 2025 — Feb 2026 [monthly]
Recruiting PHASE3
-
Aug 2025 — Nov 2025 [monthly]
Recruiting PHASE3
-
Apr 2025 — Aug 2025 [monthly]
Recruiting PHASE3
▶ Show 6 earlier versions
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Feb 2025 — Apr 2025 [monthly]
Recruiting PHASE3
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Nov 2024 — Feb 2025 [monthly]
Recruiting PHASE3
-
Sep 2024 — Nov 2024 [monthly]
Recruiting PHASE3
-
Aug 2024 — Sep 2024 [monthly]
Recruiting PHASE3
Status: Not Yet Recruiting → Recruiting
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Jul 2024 — Aug 2024 [monthly]
Not Yet Recruiting PHASE3
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Feb 2024 — Jul 2024 [monthly]
Not Yet Recruiting PHASE3
First recorded
Eligibility Summary
The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis (AK) will improve vision. Patients presenting to all enrollment centers with evidence of acanthamoeba keratitis will be eligible for the trial if there is evidence of ocular inflammation after 4 weeks of anti-amoebic therapy. Those who agree to participate will be randomized to one of two treatment groups: * Group 1: Topical corticosteroid * Group 2: Topical placebo
Contact Information
- Aravind Eye Care System
- Baylor College of Medicine
- Columbia University
- Federal University of São Paulo
- Jeremy Keenan, MD, MPH
- Johns Hopkins University
- Moorfields Eye Hospital NHS Foundation Trust
- National Eye Institute (NEI)
- Oregon Health and Science University
- University of Colorado Denver - Anschutz Medical Campus (UCD-AMC)
- University of Florida
- University of Illinois at Chicago
- University of Iowa
- University of Miami
- University of Pennsylvania
- University of Pittsburgh
For direct contact, visit the study record on ClinicalTrials.gov .