Recruiting PHASE1 INTERVENTIONAL 3-arm NCT06234423

A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors

A Phase 1, First-in-Human Study of CUSP06, a Cadherin-6 (CDH6)-Directed Antibody-Drug Conjugate, in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors

Sponsor: OnCusp Therapeutics, Inc.

Conditions Ovarian Cancer Solid Tumor

Interventions CUSP06

Updated 11 times since 2024 Last updated: Jan 12, 2026 Started: Feb 9, 2024 Primary completion: May 30, 2027 Completion: Oct 31, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Ovarian Cancer and Solid Tumor and is currently actively recruiting participants. OnCusp Therapeutics, Inc. leads this study, which shows 11 recorded versions since 2024 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

11 versions recorded

Feb 2026 — Present [monthly]

Recruiting PHASE1
Nov 2025 — Feb 2026 [monthly]

Recruiting PHASE1
Jun 2025 — Nov 2025 [monthly]

Recruiting PHASE1
Apr 2025 — Jun 2025 [monthly]

Recruiting PHASE1
Sep 2024 — Apr 2025 [monthly]

Recruiting PHASE1

▶ Show 6 earlier versions

Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE1
Jun 2024 — Jul 2024 [monthly]

Recruiting PHASE1
May 2024 — Jun 2024 [monthly]

Recruiting PHASE1
Apr 2024 — May 2024 [monthly]

Recruiting PHASE1
Mar 2024 — Apr 2024 [monthly]

Recruiting PHASE1

Status: Not Yet Recruiting → Recruiting
Feb 2024 — Mar 2024 [monthly]

Not Yet Recruiting PHASE1

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

OnCusp Therapeutics, Inc.

Data source: OnCusp Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Boston, United States , Denver, United States , Fairfax, United States , Grand Rapids, United States , Houston, United States , Miami Beach, United States , Nashville, United States , New Haven, United States , New York, United States , Oklahoma City, United States and 3 more locations