deltatrials
Recruiting PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT06238921

Sacituzumab Govitecan and Zimberelimab w/SRS in the Management of Metastatic Triple Negative Breast Cancer With Brain Metastases

Phase I/II Study of Stereotactic Radiation and Sacituzumab Govitecan With Zimberelimab in the Management of Metastatic Triple Negative Breast Cancer With Brain Metastases (TARGET-TNBC)

Sponsor: Gilead Sciences

Updated 13 times since 2024 Last updated: Dec 3, 2025 Started: Dec 19, 2024 Primary completion: Feb 28, 2027 Completion: Feb 28, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Breast Cancer and Triple Negative Breast Cancer, this trial is actively recruiting participants. The trial is conducted by Gilead Sciences and has accumulated 13 data snapshots since 2024. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jun 2024 · 2 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Oct 2025 · 4 months · monthly snapshot~Oct 2025 – ~Jan 2026 · 3 months · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

13 versions recorded
  1. Jan 2026 — Present [monthly]

    Recruiting PHASE1/PHASE2

  2. Oct 2025 — Jan 2026 [monthly]

    Recruiting PHASE1/PHASE2

  3. Jun 2025 — Oct 2025 [monthly]

    Recruiting PHASE1/PHASE2

  4. Mar 2025 — Jun 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. Dec 2024 — Mar 2025 [monthly]

    Recruiting PHASE1/PHASE2

    Status: Not Yet RecruitingRecruiting

Show 8 earlier versions
  1. Nov 2024 — Dec 2024 [monthly]

    Not Yet Recruiting PHASE1/PHASE2

  2. Oct 2024 — Nov 2024 [monthly]

    Not Yet Recruiting PHASE1/PHASE2

  3. Sep 2024 — Oct 2024 [monthly]

    Not Yet Recruiting PHASE1/PHASE2

  4. Aug 2024 — Sep 2024 [monthly]

    Not Yet Recruiting PHASE1/PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Not Yet Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  6. Jun 2024 — Jul 2024 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  7. Apr 2024 — Jun 2024 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  8. Mar 2024 — Apr 2024 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Gilead Sciences
  • H. Lee Moffitt Cancer Center and Research Institute
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations