deltatrials
Recruiting INTERVENTIONAL NCT06295471

A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser

A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a Difference Frequency Generation (DFG) Laser and Carbon Dioxide (CO2) Laser

Sponsor: Massachusetts General Hospital

Conditions Healthy
Updated 7 times since 2024 Last updated: Apr 24, 2026 Started: Oct 16, 2024 Primary completion: Mar 1, 2027 Completion: Mar 1, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A observational or N/A phase clinical study on Healthy, this trial is actively recruiting participants. The trial is conducted by Massachusetts General Hospital and has accumulated 7 data snapshots since 2024. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Study Description(click to expand)

The primary goal of this study is to compare the pain score and wound healing time in healthy subjects undergoing low fluence fractional ablation using the DFG and CO2 lasers. The secondary objective involves assessing the impact of each laser on dermal vasculature using an Optical Coherence Tomography (OCT) imaging system. Participants will be treated with the DFG and CO2 laser to the upper thighs. Photography, pain scores, and OCT imaging will be recorded over the course of the study visits. The investigators plan to enroll 23 healthy subjects to complete the study. Subjects must be equal to greater than 18 years old and may be any gender or Fitzpatrick skin type.

The primary goal of this study is to compare the pain score and wound healing time in healthy subjects undergoing low fluence fractional ablation using the DFG and CO2 lasers. The secondary objective involves assessing the impact of each laser on dermal vasculature using an Optical Coherence Tomography (OCT) imaging system.

Participants will be treated with the DFG and CO2 laser to the upper thighs. Photography, pain scores, and OCT imaging will be recorded over the course of the study visits.

The investigators plan to enroll 23 healthy subjects to complete the study. Subjects must be equal to greater than 18 years old and may be any gender or Fitzpatrick skin type.

Status Flow

~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshotNot Yet Recruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Dec 2025 · 12 months · monthly snapshotRecruiting~Dec 2025 – ~May 2026 · 5 months · monthly snapshotRecruitingMay 4, 2026 – present · 2 months · daily API

Change History

7 versions recorded
  1. May 4, 2026 — Present [daily]

    Recruiting

    Phase: NANone

  2. Dec 2025 — May 2026 [monthly]

    Recruiting NA

  3. Dec 2024 — Dec 2025 [monthly]

    Recruiting NA

    Status: Not Yet RecruitingRecruiting

  4. Nov 2024 — Dec 2024 [monthly]

    Not Yet Recruiting NA

  5. Sep 2024 — Nov 2024 [monthly]

    Not Yet Recruiting NA

Show 2 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Not Yet Recruiting NA

  2. Apr 2024 — Jul 2024 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

This research study aims assess whether the Difference Frequency Generation (DFG) laser could be a better alternative to the CO2 laser in terms of reduced side effects and patient downtime.

Contact Information

Sponsor contact:
  • Massachusetts General Hospital
Data source: ClinicalTrials.gov

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations