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Recruiting OBSERVATIONAL NCT06295965

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers (CHANCES)

Sponsor: National Cancer Institute (NCI)

Updated 7 times since 2024 Last updated: Apr 14, 2026 Started: Jan 2, 2024 Primary completion: Dec 31, 2028 Completion: Dec 31, 2031
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This observational or N/A phase trial investigates Clonal Cytopenia of Undetermined Significance and Clonal Hematopoiesis and is currently actively recruiting participants. National Cancer Institute (NCI) leads this study, which shows 7 recorded versions since 2024 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Study Description(click to expand)

OUTLINE: This is an observational study. Patients undergo blood sample collection and complete surveys on study. Patients' medical records are also reviewed.

OUTLINE: This is an observational study.

Patients undergo blood sample collection and complete surveys on study. Patients' medical records are also reviewed.

Status Flow

~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshotRecruiting~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Nov 2025 · 7 months · monthly snapshotRecruiting~Nov 2025 – ~Apr 2026 · 6 months · monthly snapshotRecruitingApr 18, 2026 – present · 5 months · daily APIRecruiting

Change History

7 versions recorded
  1. Apr 18, 2026 — Present [daily]

    Recruiting

  2. Nov 2025 — Apr 2026 [monthly]

    Recruiting

  3. Apr 2025 — Nov 2025 [monthly]

    Recruiting

  4. Mar 2025 — Apr 2025 [monthly]

    Recruiting

  5. Sep 2024 — Mar 2025 [monthly]

    Recruiting

Show 2 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting

  2. Apr 2024 — Jul 2024 [monthly]

    Recruiting

    First recorded

Jan 2024

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

This study is being done to investigate clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian or other solid cancers. Researchers want to identify risk factors for developing these blood cancers as well as if there is/are a genetic/environmental component(s) to developing blood cancer.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • University of Washington
Data source: ClinicalTrials.gov

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations